Septic arthritis in neonates due to Extended Spectrum ß-Lactamase producing Klebsiella pneumoniae - Outbreak analysis and long term follow-up
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چکیده
Between May and June 2002, we recorded an outbreak of Septic Arthritis in neonates due to Extended Spectrum ß-Lactamase producing Klebsiella pneumoniae at our neonatal intensive care unit. The confirmed cases were then followed up to look for long term morbidities associated with the infection. We analyzed the microbiological and epidemiological features of the outbreak and the various measures implemented to ward off the same. We also studied the long term morbidities associated with nosocomial infection. All neonates admitted to the NICU during this period were screened and those with clinico-microbiological evidence of septic arthritis were included in the study. Microbiological screening of the environment, personnel, patients and their attendants were conducted and 85 different environmental sites were sampled. Six neonates were confirmed to have septic arthritis after an average NICU stay of 10.00±3.16 days. Culture of synovial fluid grew K. pneumoniae. All isolates had similar biochemical and antibiotic resistance pattern suggestive of clonality of infection. Plasmid analysis of these samples revealed a single plasmid (35.8MD) in all the isolates. Similar K. pneumoniae strain with the same plasmid was isolated from the water samples which was stored Corresponding Author Dr Punith Kempegowda Clinical Fellow Post-graduate, Level 3, Ealing Hospital NHS Trust, Uxbridge Road, Southall, UB1 3HW London, UK Email: [email protected]
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تاریخ انتشار 2012